Biological buffers solubility in water

aces bes bicine bis-tris caps ches glycylglycine hepes mes mops pipes tes tricine tris saturation solubility

Most biological buffers are known for their high water solubility. This was actually one of the goals defined by Dr. Norman E. Good when he started developing some of these compounds in the 1960s.

However, the water solubility value of each “Good’s” or biological buffer varies considerably, being HEPES and Tris the most water soluble ones.

In this post we present a chart with the solubility in water of the biological buffers produced by Hopax Fine Chemicals.

 

Buffer
Useful pH range
Solubility in water

MES

5.5 - 6.7

 10g/100ml

MES Monohydrate

5.5 - 6.7

 5g/100ml

MES Sodium

5.5 - 6.7

 10g/100ml

Bis-Tris

5.8 - 7.2

 20g/100ml

PIPES Disodium

6.1 - 7.5

 3.5g/100ml

PIPES

6.1 - 7.5

 Not very soluble in water. It becomes soluble when the pH gets higher than 7 (and it is converted to the salt form).

ACES

6.1 - 7.5

 5g/100ml

MOPSO

6.2 - 7.6

 10g/100ml

BES

6.4 - 7.8

 10g/100ml

BES Sodium

6.4 - 7.8

 2.4g/100ml

MOPS

6.5 - 7.9

 10g/100ml

MOPS Sodium

6.5 - 7.9

 23g/100ml

HEPES

6.8 - 8.2

 70.36g/100ml

HEPES Sodium

6.8 - 8.2

 26g/100ml

TES

6.8 - 8.2

 5g/100ml

Tris

7.2 - 9.0

 40g/100ml

Tris HCl

7.2 - 9.0

 8g/100ml

HEPPS

7.3 - 8.7

 24g/100ml

Tricine

7.4 - 8.8

 1.8g/100ml

Glycylglycine

7.5 - 8.9

 2g/100ml

Bicine

7.6 - 9.0

 16g/100ml

TAPS

7.7 - 9.1

 5g/100ml

CHES

8.6 - 10.0

 5g/100ml

CAPSO

8.9 - 10.3

 12g/100ml

CAPS

9.7 - 11.1

 5g/100ml


Hopax Biological Buffers

Hopax Fine Chemicals is one of the largest manufacturers of biological buffers in the world. Our products are shipped daily to top research centers and biotech companies in Europe, America and Asia.

What we offer:

  • 30 buffers straight from our manufacturing sites
  • Worldwide shipping to your door
  • Assistance with shipping
  • Small and bulk packages (from grams to tons)
  • International quality standards
  • After-sales service with English speaking staff
Check the full list of Hopax Biological Buffers
Release date：2019.02.01

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